Valentines Essay Example | Topics and Well Written Essays - 500 words - 1

Valentines - Essay Example Nelly is an athletic and a rugby player in her school. For this reason, she has a buildup body that have developed out of his hobbies. She argues that she required weight to enable her play well and protect herself from other players. Moreover, being athletic make ones develop a lot of muscle out of the many exercises and to cope with the demand of the sport (London, 2015). Nelly says that she was astonished for her date to offer a gift suggesting she cut on weight (London, 2015). She argues that that was the least she expected because she always imagined that her friend like and support her involvement in sports. Nelly says that it was her resilient that made her resist knocking him down and throwing him out of the house (London, 2015). This made her cancel the date and dump his date the following day. Katie Ford is a 33 years business woman (London, 2015). She says that she is always excited to enjoy valentine day with her date. However, on February 14, 2014 she experienced a traumatic encounter after she and her date was booked for being too drunk. That evening they went to buy drink, so they have a romantic night. However, her date started drinking and promised her of so many things he would do for her. Katie though hesitant for the man ego, agreed let him have a chance. However, they did not last long on their romantic date before Katie date got too much drunk and started fighting with strangers for no apparent reason. The commotion led the owner of the restaurant to call the police to calm down Katie date. Nevertheless, the police had no choice, but to arrest the unruly man and booked him overnight until the next day. Katie romantic moment had to end and walk in the dark to her house. She says she had a walk with her high heels alone in the middle of the night because his date was not man enough. She broke up with him the

Essay Assignment Example | Topics and Well Written Essays - 2000 words - 1

Essay - Assignment Example Moreover, the modernism paradigm is inherently intertwined with culture and Eysteinsson and Liska argue that in terms of literary criticism, â€Å"modernism constitutes one of the most prominent fields of literary studies today† (Eysteinsson and Liska, 2007:1). Indeed, leading anthologist Rainey asserts that in literary terms â€Å"modernists were giants, monsters of nature who loomed so large that contemporaries could only gape at them in awe† (Rainey 2007, p.xix) However, whilst modernism is instrumental in approaching literary context, it is evident that â€Å"it is however, a field that stands in a very ambiguous relationship to the present literary and cultural situation†¦Ã¢â‚¬ ¦ scholars and critics are seeking to draw a balance sheet with modernism† (Eysteinsson and Liska, 2007:1). The concept of modernism in the cultural consciousness evolved through the end of Queen Victoria’s reign between the nineteenth and twentieth century. Indeed, Gillies and Mahood (2007) refer to publisher Grant Allen’s remarks in 1889 that â€Å"everybody nowadays talks about evolution. Like electricity, the cholera, women’s rights, the great mining boom, and the Eastern question, it is â€Å"in the air† (In Gillies & Mahood, 2007: 3). To this end, it is evident that the cultural transition between the nineteenth and twentieth century towards a modernist socio-cultural model is a central causal factor in explaining the particular distinction of early twentieth century literature in the modernist discourse. For example, if we consider this proposition contextually, Gillies and Mahood refer to Aldous Huxley’s female protagonist Lucy Tantamount in â€Å"Point Counter Point† (1928) comments that â€Å"living modernly’s, living quickly†. Moreover, constant references to â€Å"make it new† meshed â€Å"itself in ever increasingly formalised definitions of

How can Starbucks react to the threat of McDonalds selling low cost Essay

How can Starbucks react to the threat of McDonalds selling low cost coffee - Essay Example I would be failing in my duty if I don’t thank all those employees of Starbucks and McDonalds who responded to the phone calls and e-mails sent to these organizations. Last but not the least, I would like to thank all my friends who have been supporting and helping me with this assignment. Table of Contents Contents Pages Executive Summary 4-5 Introduction 5 McDonald’s Vs Starbucks 5-6 Problem for Starbucks 6 Sources of Information 6-7 SWOT Analysis 7-8 Financial Analysis 8-9 Findings 10 Recommendations 10-11 Appendices 12-25 Works Cited 26 How Can Starbucks React to the Threat of McDonalds Selling Low Cost Coffee? Executive Summary Starbucks and McDonald's are big multinational companies that have made their presence felt in the businesses they operate in. Seattle based Starbucks was founded with the objective of providing Italian espresso bar experience in the United States. As a business strategy Starbucks operates by forming a personal relationship with its consumer s. On the other hand McDonalds is a family restaurant and attracts people from all age groups. Strictly speaking, both these behemoths have distinct target markets. Starbucks attracts the affluent while customers who are price sensitive are McDonald’s target market. McDonald’s has rolled out its low-priced coffee brand and in the process has started eating into the share of Starbucks. McDonald's appears well placed to become Starbucks’ biggest competitor in the specialty coffee segment in the coming years. Starbucks now has to devise strategies to counter McDonald’s move and not let its market share dip. The present paper is a commentary on ‘How can Starbucks react to the threat of McDonalds selling low cost coffee? To answer this question relevant information on both these companies has been collected from various primary and secondary sources. A comparison has been made on the business operations of both Starbucks and McDonald’s, SWOT analy sis has been carried out and finally a financial comparison has been made. Some alternatives that can be adopted by Starbucks to react to McDonald’s move have been suggested based on aforesaid analysis. I personally feel that Starbucks should not respond to McDonald’s move with a price cut, rather it should elevate the quality perception in the minds of the customer and build a set of loyal customers who are willing to pay a premium price in exchange of getting the ‘coffee experience’ that Starbucks has to offer. Introduction I have decided to write a commentary on ‘How can Starbucks react to the threat of McDonalds selling low cost coffee? I have chosen this topic since it involves two big U.S. based companies who have worldwide operations, have a huge set of loyal customer base and are well known for their quality products. Starbucks Vs McDonald’s Starbucks is Italian-style coffeehouse chain based in Seattle, Washington. The company was foun ded in 1971 and has more than 17, 000 retail stores in 60 countries. Since inception Starbucks has believed in serving the best coffee to its customers. In fact, the company delivers much more than a simple cup of high quality coffee; it ensures a wonderful experience for the customer. A look at the product portfolio of Starbucks clearly indicates that the company has a huge variety of coffee

Professional Development Plan Essay Example for Free

Professional Development Plan Essay In order to develop a plan that will address the characteristics of my group and me as a leader; a thorough review of the completed DISC assessments much be completed on an individual basis and an overall plan can be derived thereafter. The individual analyses are as follows: Individual Assessments Jeremy Conner, Jessica Mills, and Brian Tuck are all predominately categorized as cautious in style. Their tendencies include: being tense with themselves and others when under pressure, having a natural curiosity about people, being concerned about what people think, feel, and expect, having strong attachments to their personal interests, underestimating the time required to complete tasks, being intuitive and observant about situations and people, associating their self-worth with their work, and being intrigued by concepts, ideas and processes. They are known as the assessors and tend to have strong opinions about people and groups with whom you do not identify or agree. Robert Mills was predominately categorized as interactive in style. This style’s strengths include: enthusiasm, charm, persuasiveness, and warmth. The cautious style is gifted in people skills and communication skills with individuals as well as groups. They are great influencer’s. They are idea-people and dreamers who excel at getting others excited about their vision. They are optimist with an abundance of charisma. All of these qualities help them influence people and build alliances to accomplish their goals. I was predominately categorized as a dominance style. My primary motivation is accomplishing bigger and better goals according to an internal timetable. I prefer to be involved in my chosen activities from start to finish, and I  resist people who are obstacles to my achievements. My tendencies include: disliking being told what to do, or when and how to do something, being reluctant to change what I think or how I feel, delegating tasks only if absolutely necessary, acting competitively, especially when pushing myself to new levels or in new directions, making sure that production is completed on schedule, depending on plans for action and follow-up routines, and becoming tenacious and focused when under pressure. Team Development Plan Based on the analysis of the DISC assessments, I would put myself in a leadership role on the team with Robert as my supervisor, and Jeremy, Jessica, and Brian as subordinates. My style is more fit to a leadership role due to my desire to accomplish bigger and better goals. This desire allows me to look bigger picture which must be done from an upper management perspective in order to keep the company ahead of the curve in all aspects of business to avoid pitfalls. Robert’s natural charisma and persuasiveness would make him great at motivating the rest of the team. This does not mean that Jeremy, Jessica, and Bryan aren’t just as important to the team success. All workers from top to bottom are needed for a business to be successful. I strongly believe in the phrase â€Å"you are only as good as your weakest member†. For this reason, I would make sure that they were given a chance to air their grievances and make suggestions on changes that should be made. I must make sure to allow every team member to have a say in the business processes because this is a weak point of my particular style. Flexibility on my part must be a focal point to ensure that all team members feel heard and feel like they hold value in the company. Conclusion All of the information in the above plan will be closely monitored and periodic meetings will take place to allow time for all employees to voice their grievances or concerns to ensure that full compliance is being achieved. It is very important that regular monitoring is performed to ensure that the company stays on track and will help ensure the long-term success of the company. Realizing each individual’s style as well as their strengths and weaknesses will allow a more personal and individualized  approach to be taken in regards to team dynamics and goal attainment. References University of Phoenix. (2014). DISC Assessments [Multimedia]. Retrieved from University of Phoenix, LDR531 website. DISC Test and DISC Assessment: Explained. (2013). Retrieved from https://www.discinsights.com/whatisdisc#.VBMXGGOEzSg

Treatments for Metronidazole-Resistant Giardiasis A Review

Treatments for Metronidazole-Resistant Giardiasis A Review Nicole Wagner Abstract Giardiasis is a protozoal infection and a health issue in many parts of the world for both humans and animals. Giardia spp. Are responsible for diarrheal diseases, and current treatments are not consistently effective due to the development of drug resistance. The common drugs used to treat the parasite often have undesirable side effects. New drugs, drugs previously used for other conditions, and natural remedies are all being investigated for use in treating giardiasis and reducing Giardia numbers. The mode-of-action and potency of these alternative treatments give insight into new therapies, although more research is needed. Introduction Protozoal Giardia spp. Occur in two forms, a motile, flagellated trophozoite, and a resistant cyst. The motile trophozoite adheres to the intestinal wall of its host, while the cyst form is passed in the hosts feces then re-ingested in another host (Hendrix and Robinson 2012). It is now suspected that Giardia is species specific and the human forms are included in the Giardia lamblia assemblage and include Giardia intestinalis and Giardia duodenalis (Hendrix and Robinson 2012). Giardiasis is caused by a protozoal parasite that is responsible for health issues worldwide in humans and animals. In humans, the parasite is responsible for approximately 184 million cases of giardiasis each year (Hart et al. 2015). In animals, it has been found that in North America some herds of dairy calves have the parasite in 100% of the animals, and in Australia, the most common enteric parasite of dogs is a species of Giardia (Thompson. 2000). Signs and symptoms of giardiasis include chronic and acute diarrhea and vomiting (Hart et al. 2015). These significant intestinal diseases can decrease appetite, cause malabsorption, malnutrition and even death (El-Taweed 2015). And because this parasite is found in domesticated animals, there is a significant zoonotic transmission potential (Thompson. 2000). A calf can shed 105 to 106 cysts per gram of feces, and re-infection can occur with ingesting as few as 10 cysts. As the Giardia cysts survive well in water there is a potential f or contamination of untreated water supply as well (Thompson 2000 and Watkins and Eckmann 2014). There is no vaccine available for Giardia, so the treatment of the disease involves drug therapy, like the antibiotic metronidazole, a 5-nitroimadazole class drug (Watkins and Eckmann 2014 and Hart et al. 2017). Other drugs of this class are also used to treat giardiasis with varying degrees of success. However, like many antibiotics some drug resistance has been found (Watkins and Eckmann 2014). Several studies demonstrate Giardia spp. resistance to the 5-nitroimadazole class of drugs, including one that recorded 22% of patients in a clinic in Spain receiving treatment for giardiasis did not respond to metronidazole (El-Taweed 2015). Perhaps contributing to the problem of emerging drug resistance, are the undesirable side effects of common antiprotozoal drugs. Some of these side effects include intestinal discomfort, flatulence, nausea, vomiting, and the metallic taste of the drugs (Sahib et al. 2014). It is human nature to stop using a drug with these side effects as soon as it seems to be working, and this leads to the potential for an increase in 5-nitroimidazole drug resistance over time. Also, the use of the 5-nitromadazole class drugs at lower doses for treating gingivitis and pre-surgical colorectal cases, may allow for the growth of drug-resistant forms of Giardia (El-Taweed et al. 2015). Research into how Giardia become resistant to metronidazole and the active components of other successful drugs is important to the success of treating giardiasis in humans and animals. The investigations into different drugs and herbal remedies involve identifying the mode-of-action, how the active component is effectiv e against this protozoan in both trophozoites and cyst form (Galeh et al. 2016). As an alternative to metronidazole, older antibiotic drugs, new antibiotic drugs and plant extracts and essential oils are being considered by many researchers. Newer drugs are being considered to overcome Giardia resistance like auranofin, a drug currently prescribed for rheumatoid arthritis (Watkins and Eckmann 2014.). Researchers are also considering plants and plant extracts for a new anti-giardia agent. These extracts have been used in traditional medicine to treat diarrhea in places in South America, India, Iran, and Turkey where Giardia is endemic (Watkins and Eckmann 2014). Research has been done investigating compounds from garlic (Mikaili et al. 2014), ginger and cinnamon (Mahmoud et al. 2014), pomegranate (Al-Megrin 2017), and native plants from Brazil (Martins et al. 2015), the Yucatan (Sergio et al. 2005) and their effectiveness against Giardia. Identifying the compounds in the plants that are most effective against the protozoa will provide another option for treatment of giardiasis. Drug Therapies As previously mentioned, the number of cases of Metronidazole-resistant giardiasis is growing. Other 5-nitroimadazole and nitro-class drugs have been tested against Giardia like nitazoxanide and furazolidone (Watkins and Eckmann 2014). These drugs work by reducing the nitrogen group on the drug compounds to activate toxic free radicals. The advantages of the new drugs are shorter length of treatment and reduced cellular damage to the liver and kidneys (Jarrad et al 2016). Side effects are seen in the use of these drugs, as in the case of furazolidone, where some hemolysis was observed in some patients (Watkins and Eckmann 2014) and in 5-nitroimadazole drugs side effects like nausea, vomiting and headaches are reported (Jarrad et al. 2016). When developing new drug treatments, researchers investigate how the parasite is developing resistance to current treatments. In the case of 5-nitroimodazole drugs, the potency of a substance against Giardia species is due to the activation of the drug by an enzyme pyruvate ferredoxin oxidoreductase (PFOR). The drugs nitro group is reduced by the protozoans PFOR enzyme, producing toxic free radicals which bond to target molecules in the microbe, inactivating them and killing the parasite (Watkins and Eckmann 2014). The resistant protozoans have down-regulated the PFOR enzyme (Jarrad et al. 2016 and Galeh et al. 2016). To treat giardiasis, research has focused on this nitro group and the formation of toxic free radicals. Other drugs are being developed that incorporate a benzene ring, instead of (or in addition to) the nitro groups. These drugs act on the Giardia cellular vesicles, causing swelling, and are more effective than nitazoxanide and metronidazole (Watkins and Eckmann 2014) . Not all research has resulted in support for the development of new drugs in the 5-nitromiadazole class. In a study conducted in Iran, researchers tested the theory in human clinical studies, utilizing PCR to identify genetic mutations that appeared in metronidazole-resistant Giardia lamblia. In the metronidazole-resistant G. lamblia, the protozoa did not show down regulation of PFOR and it is suspected that other predisposing factors were responsible for the drugs ineffectiveness(Galeh et al. 2016). Further research is being done to test the new drugs like nitroimidazole and furazolidone for cytotoxicity towards human liver, kidney, and intestinal cells (Watkins and Eckmann 2014). These side effects can be serious in immune-compromised subjects and children. Older antibiotic drugs like albendazole and mebendazole, benzimidazole class drugs, have been shown to be effective against Giardia as well. These drugs are currently used to treat roundworm infections. The benzimidazole class drugs act by binding to tubulin and interfering with the protozoan cytoskeleton (Watkins and Eckmann, 2014). Research into the effectiveness of metronidazole and albendazole in mice showed that some Giardia isolates developed resistance to one or the other drug and in some cases both drugs (Lemà ©e et al. 2000). In the case of albendazole, some Giardia duodenalis resistance developed in a mouse model (Lemà ©e et al. 2000). In another study in Bolivia when albendazole was used to reduce the hookworm infection, the number of Giardia infections increased showing some (Watkins and Eckmann 2014). Drug research of existing drug libraries has also revealed some drugs that previously were not used as antimicrobials are effective against Giardia. A drug used for rheumatoid arthritis, auranofin, inhibits the growth of metronidazole-resistant Giardia. It works by inhibiting the thioredoxin-glutathione reductase enzyme (Watkins and Eckmann 2014). A drug used for obesity treatment, orlistat, which is poorly absorbed, is active in the intestine. Orlistat works by inhibiting lipases in Giardia isolates, preventing lipid metabolism (Watkins and Eckmann 2014). Ginger and Cinnamon Current research into metronidazole-resistant Giardia infections has gone beyond investigating new drugs or existing drug libraries. Diarrheal treatments around the world have shown promise in providing avenues for new giardiasis therapies and treatments. Some of this research involves the investigation into anti-nausea spices, ginger and cinnamon. Research has been conducted using ginger extracts in both in vivo and in vitro studies. In an in vitro study (Abdel-Hafeez et al. 2016), a comparison was made between gingers and nitazoxanides effectiveness against Giardia lamblia trophozoites. Ginger was chosen to contrast with the drug because of its historical use as an anti-nausea and anti-diarrheal treatment. Ginger extract is an antioxidant with alkaloids, saponins, tannins, and flavonoids. It is suspected that either the antioxidant or flavonoids have a negative effect on the trophozoites (Mahmoud et al. 2014). A study investigated curcumin, an antioxidant, also found in Zingiber officinale and other pungent spices (Perrez-Arriaga et al. 2006) showed that in the presence of curcumin at concentrations similar to metronidazole, significant swelling was seen in the Giardia trophozoites, indicating possible cell membrane interference (Perrez-Arriaga et al. 2006). In the research conducted by Abdel-Hafeez et al. (2016), cultured fecal samples treated with ginger extract at 20mg/mL resulted in similar reduction of the number of viable trophozoites in the culture as nitazoxanide. The findings were based on counts of viable trophozoites (pear-shaped, mobile, and non-refractory quality) under a light microscope. Verification of findings may use in vivo studies with mice or rats, and improved counting and staining techniques are indicated for future research. Meanwhile, ginger continues to be used for a variety of intestinal infections in Thailand, India, and Egypt (Abdel-Hafeez et al. 2016). In the in vivo study by Mahmoud, et al (2014)., cinnamon was also evaluated against Giardia trophozoites and cysts. As stated previously, the cyst is found in fecal samples as a transmissible form. The researchers This study involved using Giardia lamblia cyst infected rats and measured doses of ginger at 10 and 20 mg/kg/day and cinnamon at 10 and 20 mg/kg/day. As Perrez-Arriaga et al. (2006) previously researched, active compounds in ginger may affect the protozoans cell membrane. In another study, Proanthocyanidins were identified as an active compound in cinnamon (Williams et al. 2015). Proanthocyanidins, also found in berries, disrupt protozoans adhesive ability which is necessary for the trophozoite to maintain its position in the intestine (Anthony et al. 2007). In the Mahmoud study (2014) the rats were euthanized and their intestines washed for a measurement of trophozoites and to determine intestinal damage (Anthony et al. 2007). Their stools were also collected for three day s prior to euthanasia to perform a count of cysts excreted (Mahmoud et al. 2014). According to the results of this study, cinnamon given to the rats at the 20 mg/kg dose resulted in a 100% reduction in the number of cysts found in their fecals, and a 34% reduction in the number of trophozoites. When rats were given a dose of 20mg/kg of ginger the number of cysts found in their stool was reduced by 90.1% and the number of trophozoites in the intestinal wash was reduced by 75.45%. So, the cinnamon was more active against cysts and the ginger was more active against the trophozoites in the rats (Mahmoud et al. 2014). The study also utilized electron microscopy to count and identify Giardia cysts and trophozoites. By utilizing this technology, and the researchers were able to show that not only was the infection reduced with cinnamon, but the intestinal mucosa was healthier in the samples taken as compared to the ginger-dosed rats (Mahmoud et al. 2014). This study, however did not utili ze a positive control group to measure the difference (if any) between using ginger and cinnamon extracts compared with using metronidazole or other drug treatment for giardiasis. Additional research may determine whether the intestinal mucosa would improve, with the drug treatment as occurred in the study with cinnamon and ginger (Mahmoud et al. 2014). Garlic and Shallot One of the most promising and researched herbal extract is allicin, a component of plants in the garlic and onion family. Garlic and shallot plants have been used in traditional medicine in various parts of the world for hundreds of years (Mikaili et al. 2013). Sulfur-based components like allicin (diallyl dithiosulfinate), diallyl disulfide, and S-allylcystein of these plants are of interest to research for use in pharmacological studies (Mikaili et al. 2013). In an in vitro study investigating whole garlic extract (Harris et al. 2000), garlic was shown to be effective against Giardia intestinalis at a concentration of 0.3mg/mL. The researchers went on to examine how the compounds in garlic were acting on the Giardia and whether allicin was the compound of interest. Allicin has a very short half-life in vivo, but the thiosulfates that result from its breakdown are bioavailable longer to act against Giardia trophozoites (Harris et al. 2000). In this study the researchers investigated the anti-parasitic activity of these compounds, and they showed that diallyl disulphide was particularly effective in reducing the number of trophozoites. Another component, allyl alcohol, damaged the trophozoites by causing cellular swelling and immobility (Harris et al. 2000). In another study focusing on diallyl trisulfide (DAT) from garlic, a concentration of 300 ug/mL was effective against Giardia lamblia (Lun et al. 1994). The researchers used an in vitro test to determine the IC50 for DAT, and the result was 8.5-14 ug/mL, using the same tests that determined the IC50 of metronidazole. The use of DAT in China for treatment of other parasitic infections is not uncommon (Lun et al. 1994), but it will be necessary to determine how DAT is effective against the parasite in vivo in future research. One avenue that research may pursue is in studying how DAT affects tubulin (Hosono et al. 2005), which would indicate that this substance has a similar effect as the benzimidazole drugs like albendazole. Further research into obtaining effective concentrations of these components of garlic and onions is necessary. Herbal Extracts Other herbal extracts have been investigated for their biologically active components and effectiveness as a treatment for giardiasis. Three of these show promise in recent studies. Peppermint (Mentha x piperta L.) is used as an herbal remedy for stomach discomfort (Vidal et al. 2007). Dill is also used in some areas of the world to treat children with diarrhea (Sahib et al. 2014). Pomegranate peel contains some substances that prove active against Giardia (Al-Megrin 2016). Mentha x piperta (peppermint) is known to have a relaxation effect on gastrointestinal smooth muscle, and this is suspected to be the result of the menthol affecting calcium channels (Kiefer et al. 2008). In one study methanolic extract from Mentha x piperta was tested against Giardia lamblia (Vidal et al. 2007). This study measures IC50, which is the calculation of the amount of a substance necessary to inhibit or kill one-half of the microbes. The IC50 after 48 hours of exposure was 0.8 ug/mL, similar to the IC50 of metronidazole and furazalidone after 24 hours (Vidal et al. 2007). The study tested different concentrations of the dichloromethane (DCM) from Mentha x piperta and found that a dose of 100 ug/mL after 48 hours almost eliminated the presence of trophozoites in the culture media (Vidal et al. 2007). The study also examined how DCM was altering the morphology of trophozoites utilizing electron microscopy, and found changes to plasma membranes (Vidal et al. 2007). This sugg ests the need for further research into why the protozoal membranes were altered, what biologically active components of peppermint were involved, and whether this alteration would also affect intestinal cells in mammals (measuring potential toxicity). In a study that researched the extracts from the Dill plant (Anethum graveolens), researchers conducted a clinical trial with children Giardia trophozoites and cysts, or if the dill acted on the muscle cells in the intestine, reducing smooth muscle contraction. Further research needs to be conducted into these issues. Pomegranate peel extract was also tested for anti-Giardia activity in another study (Al-Megrin 2016). Researchers studied mice that were infected with the Giardia cysts, and given an extract of pomegranate peel daily. Then the number of cysts produced in the mouse stool and the antigen presence for Giardia were counted and measured respectively. There was a reduction in the number of cysts counted in the groups of mice that had received the pomegranate, however there was also a natural reduction in the number of cysts in the studys control group (Al-Megrin 2016). The researchers also reported that the rate of detection of the Giardia antigen in the groups that were treated was significantly (P Native Plants Ethnopharmacology is becoming one method for identifying plant-based sources for new pharmacological treatments. Ethnopharmacology studies involve interviewing people who are native to specific areas to identify historical and current plant species used to treat disease. In the case of Giardia treatment, researchers identified diarrhea as the key symptom in 90% of human cases (Neiva et al. 2014). Although people reporting to clinics or hospitals with diarrhea did not necessarily identify causative agents, in some cases they were self-treating with plants from the area or from their own gardens (Neiva, et al. 2014). The identification of plants used by people suffering from diarrhea allowed researchers to focus on specific plant species in anti-giardiasis studies. In one study by Neiva et al. (2014) the researchers focused on an area around Sao Luis, Brazil. From interviewing and collecting plant samples that people were using to treat diarrhea and dysentery symptoms, the researchers identified five potential plants to test for anti-Giardia effectiveness. The researchers also identified the part of the plants and the preparation of the plants used for treatment of diarrhea by these patients of a healthcare facility and private specialty institution (Neiva et al. 2014). The five species of plants selected to investigate were Anacardium occidentale L., Chenopodium ambrosioides L., Passiflora edulis Sims., Psiddiumguajava L., and Stachytarpheta cayennesis (Rich) Vahl. (Neiva et al. 2014). It was found that all the plants had some giardicidal activity, but Passiflora was most effective at IC50 In another similar ethnopharmacology study, researchers investigated plants native to the Yucatan peninsula in Mexico that were used to treat diarrhea (Paraza-Sanchez et al. 2005). This study was conducted in vitro using 10 methanol extracts from native plants. In this study Tridax procumens as a whole plant was used (air-dried and powdered into methanol, then evaporated, and added to DMSO) (Paraza-Sanchez et al. 2005). The researchers identified from other studies that the plant contains hydrocarbons, fatty acids, flavonoids, bis-bithiophene. Flavonoids may contain polyphenols and inhibit Giardia from adhering to the intestinal wall (Anthony et al. 2007) In other plants tested, C. dentata, D. cahagenesis, and B. cressifolia have not had their chemical components analyzed, although they all had giardicidal activity (Paraza-Sanchez et al. 2005). It is unknown at this time why these native plants are effective against Giardia spp. (Paraza-Sanchez et al. 2005). Research has been conducted on the Rubus liebmanii medicinal plant native to Mexico. The antiprotozoal active compounds were identified as epicatechin and catechin (polyphenols), Nigaichigoside F1, beta-sitosterol, squalene, and 3,4 hydroxybenzoic acid (Jimà ©nez-Arellanes et al. 2012). In this study, extracts from the plant were fractionated to identify specific compounds, an extract of R. liebomanii was tested against G. lamblia with a negative control and a metronidazole infused positive control, and the research continued using guinea pigs and mice as test subjects. The results indicated that the Nigaichigoside F1 had an IC50 of 2.17 ug/mL as compared with metronidazole which had an IC50 of 0.5 ug/mL in cultures of G. lamblia (Jimà ©nez-Arellanes et al. 2012). When the potential toxicity of the plant was tested in male rats, the pure extract of R. liebmanii was not toxic, even at 1000mg/kg dosages (Jimà ©nez-Arellanes et al. 2012). Further research into these plants may involv e identifying how the active components are working against the protozoans and identify more effective treatments, which will need to be tested in vivo. Solanum lycoparum is also a native plant of Brazil. In research published in 2015 (Gilmarcio et al. 2015), this native species was investigated for its anti-Giardia potential. The fruit of this plant is used in traditional medicine (Gilmarcio et al. 2015). Two glycoalkaloids, solamargin (Sg) and solasonine (Sn) have been identified as having potential as anti-Giardia treatments (Gilmarcio et al. 2015). Both compounds were effective against Giardia lamblia, with Sg having an IC50 of 120.3 ug/mL and Sn having an IC50 of 103.7 ug/mL. However, when both compounds were mixed as they would be in the fruit of S. lycoparum, their IC50 was 13.23 ug/mL, much lower (Gilmarcio et al. 2015). This demonstrates a synergistic effect of the compounds. The researchers also used an index of selectivity calculation to measure effectiveness of the compound as compared to toxicity against macrophages, and the combined glycoalkaloids had a relatively high index (Gilmarcio et al. 2015). This index was neces sary because glycoalkaloids can be toxic. In vitro studies of the combined Sn+Sg treatment would provide additional research opportunities and determine the toxic effects of the glycoalkaloid while treating Giardia lamblia. Glycoalkaloids affect permeability of mammalian intestinal cells (Gee et al. 1996), however the glycoalkaloids found and studied from the S. lycoparum are not the most toxic. It is likely; however, no research could be found in the current literature searches, that the effect of glycoalkaloids on the Giardia trophozoites cell membrane did cause cellular swelling and changes to the vesicles and flagella. Essential Oils Clove oil, an essential oil from Syzgium aromaticum, has been used to treat digestive disorders and diarrhea (Machado et al. 2011). Research into essential oils has shown they are effective against many bacterial and fungal infections, but little research has been done to discover how the oil works (Machado et al. 2011). Eugenol is a major of several essential oils including S. aromaticum, and in this research the eugenol comprised 85% of the essential oil tested (Machado et al. 2011).In a study testing the effect of clove oil and eugenol on Giardia lamblia it was shown that S. aromaticum had an IC50 value of 134 ug/mL and eugenol had an IC50 value of 101 ug/mL (Machado et al. 2011). The study also utilized scanning and transmission electron microscopy to measure morphological changes in the Giardia that were incubated with the S. aromaticum essential oil. It was observed that the adherence of the Giardia was inhibited in the presence of eugenol (Machado et al. 2011). Giardia normall y attach to the intestinal wall to maintain position, obtain nutrients, and reproduce. The essential oil contained eugenol, and although it affected adherence, it did not cause the Giardia trophozoites to lyse, so the results in this study indicated that other components of the S. aromaticum oil were responsible for the cell death (Machado et al. 2011). Other essential oils are used to treat digestive issues. One, from Ocimum basilicum of the basil family, was studied for its anti-Giardia effects (de Almeida et al. 2007). In this study the researchers again isolated components of the essential oil and tested for antigiardial activity (de Almeida et al. 2007). This study also investigated eugenol as one of those components, and found the eugenol was effective against the Giardia trophozoites (de Almeida et al. 2007). The study included testing the linalool, which makes up 69.33% of the essential oil in addition to eugenol. Linalool was shown to be even more effective at reducing the number of viable Giardia lamblia trophozoites (de Almeida et al. 2007). To verify potential toxicity of the essential oil and its components, the researchers tested mouse macrophages in the same concentrations of Ocimum basilicum, eugenol and linalool and found that there was little to no effect on the cells (de Almeida et al. 2007). The researchers also identified an inhibitory effect of the oil and it components to a group of cysteine peptidases enzymes that are commonly found in these protozoans (de Almeida et al. 2007). The inhibition of cysteine peptidases has been shown to have a lethal effect on trophozoites of another protozoal species, Entamoeba histolytica (Ankri et al. 1997). Ozone In an interesting study (Boland-Nazar et al. 2016), olive oil injected with ozone was tested as a treatment for giardiasis. In an in vitro study, the tubes of Giardia were combined with different concentrations of ozonated olive oil, and this proved effective against Giardia cysts after 100 hours of incubation (Boland-Nazar et al. 2016). It is suspected by the researchers that the extra oxygen atom acts a free radical, like the immunological response of macrophages and neutrophils (Boland-Nazar et al. 2016). Olive oil is effective at stabilizing a delivery system for ozone without losing its durability (Boland-Nazar et al. 2016), and the higher the concentration of ozone in the oil, the more effective the treatment is against Giardia cysts. The researchers suggest conducting an in vivo study with this substance to verify their hypothesis (Boland-Nazar et al. 2016). Discussion Research into treating giardiasis will continue as standard treatments like metronidazole go up against greater drug resistance. The mode of action of different therapies has been investigated and includes inhibiting PFOR, cysteine proteinases, inhibiting adherence (Anthony et al. 2007), tubulin and cytoskeleton interference, and cell membrane interference. Table 1 shows some of the different treatments dosage requirements and active compounds. The 5nitroimadazole drugs are the most commonly prescribed treatments for giardiasis world-wide. New drugs are being developed from within this class, altering the nitro-group or adding benzene rings to the molecules to improve effectiveness considering growing metronidazole resistance (Watkins and Eckmann 2014). Other drugs that have been prescribed for anti-parasitic treatment or other purposes entirely are also being investigated. This includes anthelminthic drugs as well as drugs that were initially developed to treat obesity and rheumatoid arthritis (Watkins and Eckmann 2014). Finally, herbal, spice, and plant-based extracts are being investigated for their antiprotozoal activity. Although Table1 does not show an IC50 for each of the compounds discussed in this paper, it does highlight the active components. Table 1: Effectiveness of different substances in inhibiting Giardia IC50 Active compound Reference Metronidazole 0.8 ug/mL 5-nitroimadazole Jarrad et al. 2016, Watkins and Eckmann, 2014, Vidal et al 2007 Albendazole 52.4 ug/mL Benzimidazole Jarrad et al. 2016, Watkins and Eckmann, 2014, Lemee et al. 2000 Furazolidone 0.65 ug/mL 5-nitrofurans Jarrad et al. 2016, Watkins and Eckmann, 2014, Vidal et al 2007 Garlic 14 ug/mL Diallyl trisulfide Lun

Coco Chanel Essay -- Fashion Designers Essays

Coco Chanel In his 1993 book, Creating Minds, Howard Gardner attempted to distinguish characteristics that were common to creative people. In doing so, he concluded that many factors were involved in the development of a creator. For instance, the relationship between the Individual, the Work, and Other People (i.e. family and colleagues) (Gardner 9) was elemental in predicting future successes. Likewise, part of his hypothesis focused around the fact that creators typically make their mark in one single genre. He divided the types of work that could be created into seven different areas: interpersonal, intrapersonal, visual/spatial, logical/mathematical, musical, verbal/linguistic, body kinesthetic (Gardner vii). Gardner's rubric for finding commonalties amongst creators, or those people who produce innovative, influential works in their particular domain, has become a highly regarded and widely used tool for identifying creative genius. Likewise, one key factors promoting creativity was the marginal status of the creator. Gardner briefly mentions the importance of the relationship between the creator and their society (Gardner 42). In my opinion, Gardner gives too little attention to the importance of one's marginal status. I intend to show, through the example of Coco Chanel, that marginality can have an imperative impact on the development of one's creativity. Therefore, I will fit Chanel into the prescribed rubric that Gardner outlined in his book, and show how her marginal status defined her as well as her work. Part One: The Personal History of Chanel Chanel was born in 1883, illegitimately (Charles-Roux 9/3) to a father that would soon desert her, and a mother who would die by the time she reached the age ... ... different perspective on things. Perhaps she was "creative" because she did not know how to be "traditional." Maybe what seemed normal to Chanel, what felt natural for her, was simply different from what was normal for others. In any case, I feel that Chanel's marginal status was the main catalyst for her success as a fashion designer. Gardner overlooked the degree of importance that should be attributed to a creator's marginality. For in the end, to create is to do something original, what has never been done before. And to do something unique should mean to be unique. And to be unique and creative means to be marginal. Bibliography Charles-Roux, Edmonde. Chanel and Her World. The Vendome Press: London. 1979. Gardner, Howard. Creating Minds. Basic Books: New York. 1993. Madsen, Axel. Chanel: A Woman of Her Own. Henry Holt and Co.: New York. 1990.

Geometry Kite Making

1) Search for a kite you’d like to build. It can be any shape kite, but keep in mind that the easier the build, the more difficult I grade it. The harder it is to build, the more chance it won’t be completed in time. So evaluate yourself & the directions to determine which kite you decide on building. a. Google the web (not videos, nor images) – â€Å"How to build a kite with step by step directions† †¦ You can word your search in any way that is similar to what I just gave you. b. Be sure what you pull up has Step by Step Directions on how to build the kite (i. e. t will tell exactly how & where to cut the material, where to place the dowels, where to tie the string, etc, etc).c. Be sure what you pull up has Clear Materials Listed – meaning you will be able to list off what is needed to build a kite (i. e. exact centimeters or inches of dowels, the diameter of the dowel, if plastic tubing is needed, string length, etc, etc). d. Print all this out – preferably with photos (always helpful when building). 2) Write up a materials list with the totals (dowel length, string length, fabric, etc) on a lined piece of paper so that it’s legible.This is for me to go shopping with, so I need the exact total & I need to read it. I’m not interested in how many ___ sized pieces of dowel you need because we’ll just cut up the total length later; I just need you to calculate from your internet, printed materials list the exact totals of each item. 3) Build your kite – we’ll be doing this in class as a group. You won’t be taking any of these items home, so you need to make sure you are here for each class we designate as build days. e.Each â€Å"build day† you will need: yard stick (science lab has some), pencil, pen, lined paper for calculations, calculator, ruler, protractor, kite instructions & a servant’s heart (because we’ll need to bring other items to & from my c lassroom each of these days = teamwork). f. Measure the perimeter & area of your kite, once completed. g. Were there any angles in your kite? What types; how many; what degrees were they (calculate algebraically being sure to write down how you calculated †¦ same side interior, complementary angles, etc. )? h.Are there any parallel &/or perpendicular lines? Transversal lines? i. As you build along, rewrite the steps in your own words so that someone else could build your kite. Use as many geometric terms as articulately possible. Reason: 1) I asked; and, 2) the directions you find on the internet are often more complicated than need be, so you’ll be helping someone else out. Maybe we’ll start our own website someday! 4) Project items from the book: j. Page 453: You’ll need to draw diagonals on a plain, white sheet of copy paper using a yard stick for accuracy.Mark off your half-inch measurement (the  ½ inch past center point) with a pencil so that it†™s visible to others. The â€Å"front corners† are considered the ones where you folded the paper, not the ones where it’s unfolded. **There is a â€Å"typo†: you’ll be folding the corners & stapling them about 3-4 in. from the front of the kite. You will staple those folds together perpendicularly to the first fold. ** Tie one end of string through the back of the staple. Open up the unfolded paper to create a kite surface. ~ You are not creating a paper airplane, and so therefore will follow these directions with the book’s directions to create a paper kite. ~~ k. Page 468: When â€Å"describing† each effective area, the book is asking you to compare the effective area to the actual kite (i. e. : does the effective area have the same area as the part of the kite that’s facing the wind; or less, or more; etc, etc). When you compare, do so in words (using as many geometrical terms as possible) as well as with some calculations.l. Pa ge 476: SKIP †¦ this is what you did in Parts 1 & 2. ) REPORT: Research the history of kites, and be sure to write down your sources for use in a reference page later (when you hand in your final project). m. When were they first used? What were they used for? In what country did they first get used predominantly? n. Find examples of how kites were used for: rescuing sailors, vanquishing enemies, predicting the weather, etc. Give me any other uses for kites †¦ be thorough & creative. o. Tell me any interesting facts you discovered about kites while doing this research.